STILLMEADOW, Inc. – Drug Development, Toxicology, Animal Health
Mammalian Toxicology
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Mammalian Toxicology Services
Considerable legislation has been developed to protect people and the environment from the harmful effects of chemicals. Acute and subchronic mammalian toxicology testing protocols provide essential data for evaluating products, informing both manufacturers and the public of potential hazards. Industries of significant economic and societal importance rely on the safe use of effective chemicals for numerous beneficial purposes.
- STILLMEADOW, Inc. offers comprehensive toxicology services for premanufacture notification, pesticide registration, labeling, and safe handling recommendations for consumers and employees.
- We adhere to guidelines set by USEPA, OECD, FDA, and other regulatory bodies.
- Studies can be conducted as GLP or non-GLP, depending on the client’s needs.
STILLMEADOW, Inc. takes pride in its ability to support industries with the necessary toxicology services to ensure the safe and effective use of chemicals.
Mammalian Acute Toxicology Studies – EPA 870.1000 – .2600 and OECD 400s
- Acute Oral Toxicity in Rats Up and Down Method ( OCSPP 870.1100, OECD 425)
- Traditional Acute Oral Toxicity in Rats (OCSPP 870.1100, OECD 401)
- Acute Dermal Toxicity in Rabbits or Rats (OCSPP 870.1200, OECD 402)
- Acute Inhalation Toxicity in Rats (OCSPP 870.1300, OECD 403)
- Acute Eye Irritation in Rabbits (OCSPP 870.2400, OECD 405)
- Acute Dermal Irritation in Rabbits (OCSPP 870.2500, OECD 404)
- Skin Sensitization – Guinea Pig – Buehler Method (OCSPP 870.2600)
- Skin Sensitization – Guinea Pig – Magnusson Kligman Method
- Skin Sensitization – Mouse – Local Lymph Node Assay (OCSPP 870.2600, OECD 429)
- Acute Oral Toxicity/Pathogenicity OPPTS 885.3050
- Acute Dermal Toxicity/Pathology OPPTS 885.3100
- Pulmonary Toxicity/Pathogenicity OPPTS 885.3150
- Acute Injection Toxicity/Pathogenicity OPPTS 885.3200
Pre and post tox analyses are available in the absence of a Certificate of Analysis (CofA). Following specific guidelines or charting new water, let us help develop your custom protocol that suits you specific needs.
Need basic toxicology analysis for your adjuvants for CPA Certification? You will need to start with these 3 basic tests. Acute Oral Toxicity, Acute Eye Irritation and Acute Dermal Toxicity.
Frequently Asked Questions
Mammalian toxicology is the study of the adverse effects of chemicals, drugs, or other substances on mammalian species, including humans. It involves assessing the potential risks these substances pose to mammalian health through various testing methodologies.
Mammalian toxicology testing is crucial for determining the safety of chemicals, pharmaceuticals, consumer products, and environmental contaminants. It helps identify potential hazards and informs risk assessment and regulatory decision-making to protect human and animal health.
Mammalian toxicology studies follow standardized protocols and guidelines established by regulatory agencies such as the FDA and EPA. They involve administering test substances to animals via various routes (oral, dermal, inhalation, etc.) and monitoring them for adverse effects over specific periods.
Stillmeadow, Inc. provides expert guidance and support throughout the regulatory submission process, including study design, protocol development, data collection, analysis, and report generation, to facilitate successful regulatory approvals.
Stillmeadow, Inc. adheres to strict ethical standards and animal welfare guidelines in all mammalian toxicology studies. We prioritize the humane treatment of animals, minimize suffering, and employ alternative methods whenever possible to reduce the use of animals in testing.
Stillmeadow, Inc. offers a comprehensive range of mammalian toxicology services, including acute toxicity testing, subchronic and chronic toxicity studies, carcinogenicity assessments, reproductive toxicity studies, and developmental toxicity evaluations.
Mammalian toxicology studies typically involve the use of rodents such as mice and rats, as well as non-rodent species like rabbits, dogs, and primates, depending on the specific requirements of the study and regulatory guidelines.
Regulatory requirements for mammalian toxicology testing vary depending on the jurisdiction and the intended use of the tested substances. Stillmeadow, Inc. ensures compliance with relevant regulations, including Good Laboratory Practice (GLP) guidelines, to meet regulatory expectations.
Yes, Stillmeadow, Inc. offers customized study designs tailored to meet the unique requirements and objectives of clients, ensuring that the studies address specific endpoints and provide relevant data for their intended applications.
For more information or to request a quote for mammalian toxicology services, please contact Stillmeadow, Inc. through our website or directly reach out to our customer service team. We are committed to providing timely and comprehensive assistance to meet your toxicology testing needs.