STILLMEADOW, Inc. – Drug Development, Toxicology, Animal Health
STILLMEADOW, Inc. specializes in conducting avian toxicology testing according to EPA OCSPP Ecological Effects Test Guidelines. We conduct GLP non-target guideline avian testing with test substance administration by oral, inhalation and dietary routes using both terrestrial species ,bobwhite quail, and water fowl species, mallard duck.
We conduct Avian Oral Toxicity Tests with microbials and biopesticides (885.4050), and conventional chemicals (850.2100). We do the Avian Dietary Toxicity Test (850.2200) and Avian Inhalation Test according to guideline (885.4100). Bobwhite quail is the most common species required by the regulatory agencies that we test with.
To ensure the highest quality of birds are available for testing that meet OCSPP avian toxicology guideline requirements, we incubate only disease-free certified eggs, which also ensures that we meet the requirement that all chicks used on a study come from the same egg hatch.
Avian Oral, Tier I, Microbial Pest Control Agent (MPCA) Test (885.4050) is conducted with chicks that must be 14-24 days old at dosing. The chicks are administered the MPCA test substance by oral gavage for 5 days and observed for 30 days for signs of toxicity or mortality. Additional groups dosed include; an inactive group dosed with the MPCA that is inactived by autoclaving, a group is dosed with the MPCA sterile filtrate vacuum filtered through a 0.4 micron filter, and an untreated control group for comparison.
Avian Acute Oral Toxicity Test (850.2100) is conducted with adult birds that must be ≥ 16 weeks old at dosing and be from the same egg hatch. The birds are administered by oral gavage a single dose and observed for 14 days for signs of toxicity or mortality.